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Nirsevimab Protects Infants Against RSV-Linked Hospitalization

THURSDAY, Dec. 28, 2023 (HealthDay News) — Nirsevimab is efficacious for preventing hospitalization for respiratory syncytial virus (RSV)-associated lower respiratory tract infection among infants, according to a study published in the Dec. 28 issue of the New England Journal of Medicine.

Simon B. Drysdale, Ph.D., from the Centre for Neonatal and Paediatric Infections at the University of London, and colleagues conducted a pragmatic trial involving infants aged 12 months or younger, born at gestational age of at least 29 weeks who were entering their first RSV season in France, Germany, or the United Kingdom. The infants were randomly assigned to receive a single intramuscular injection of nirsevimab (4,037 infants) or standard care (no intervention; 4,021 infants) before or during the RSV season.

The researchers found that 0.3 and 1.5 percent of infants in the nirsevimab and standard-care groups, respectively, were hospitalized for RSV-associated lower respiratory tract infection, corresponding to 83.2 percent efficacy for nirsevimab. Very severe RSV-associated lower respiratory tract infection occurred in 0.1 and 0.5 percent of infants in the nirsevimab and standard-care groups, respectively, corresponding to 75.7 percent efficacy. In France, Germany, and the United Kingdom, the efficacy of nirsevimab against hospitalization for RSV-associated lower respiratory tract infection was 89.6, 74.2, and 83.4 percent, respectively. Overall, 2.1 percent of the nirsevimab group had treatment-related adverse events.

"These findings suggest that nirsevimab has the potential to reduce the burden of hospitalization for RSV-associated lower respiratory tract infection among infants," the authors write.

The study was funded by Sanofi and AstraZeneca, which manufacture nirsevimab.

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Advanced Pediatric Centre With 565 Beds Coming Up At SGPGI

Lucknow: The Uttar Pradesh Cabinet on Tuesday approved the proposal for the establishment of the state's first Advanced Pediatric Center.

The centre, to be the first of its kind in the state, will be established at SG wiPGI. The centre will have various pediatric experts to treat all diseases related to children. This facility is not currently available in any institute or medical college in the state. The project is estimated to cost Rs 199 crore 10 lakh 52 thousand.

Director of SGPGI Prof. Dr RK Dhiman said that currently, 40 percent of the population in the state comprises children and adolescents aged 0-18 years. Recognizing the long-standing need for better healthcare for them, the establishment of an Advanced Pediatric Center was proposed to the Yogi government, which has now been approved in the cabinet, he added.

The centre will be established in two phases. In the first phase, 310 beds will be set up, along with 12 departments and 4 units.

The beds will include 163 normal beds, 54 ICU beds, 28 HDU beds, 20 isolation beds, and 45 private beds. In the second phase, an additional 265 beds will be included, along with 9 more departments and 2 units.

This phase will comprise the installation of 158 normal beds, 13 ICU beds, 10 HDU beds, 21 isolation beds, and 63 private beds, he further added.

The director informed that in the first phase, 12 departments and 4 units will function.

These include departments like General Pediatrics, Pediatric Oncology, Pediatric Emergency, Pediatric Critical Care, Pediatric Surgery, Pediatric Gastroenterology, Pediatric Endocrinology, etc. Meanwhile, the units will encompass Pediatric Pulmonology, Pediatric Cardiology, Day Care, and Pediatric Medical Genetics.

RK Dhiman further added that in the first phase, the majority of the 60 beds will be dedicated to General Pediatrics.

Similarly, in the second phase, an additional 9 departments and 2 units will operate, covering Pediatric Nephrology, Pediatric Neurosurgery, Pediatric Urology, Pediatric Orthopedic and Physical Medicine, etc., in the departments. The unit will include the Social Pediatrics and Developmental Pediatric Units.

UP Cabinet Gives Approval For Setting Up State's First Advanced Pediatric Center At PGI In Lucknow

LUCKNOW, Dec 19: The Uttar Pradesh Cabinet on Tuesday gave its approval for setting up the state's first Advanced Pediatric Center at PGI in Lucknow.

The cabinet meeting presided over by Chief Minister Yogi Adityanath decided the centre, to be the first of its kind in the state, will be established at PGI in Lucknow, an official release issued here said.

The centre will have various pediatric experts to treat all diseases related to the children.

This facility is currently not available in any institute or medical college of the state. The project is estimated to cost Rs 199 crore 10 lakh 52 thousand.

SGPGI Director Professor Dr RK Dhiman said that currently, 40 per cent of the population in the state comprises the children and adolescents aged 0-18 years.

Recognizing the long-standing need for better healthcare for them, the establishment of an Advanced Pediatric Center was proposed to the state government which has now been approved in the cabinet, he added.

Accordingly, an Advanced Pediatric Center consisting of more than 20 departments and six units, and equipped with 575 beds will be set up at PGI, the release said.

The centre will be established in two phases. In the first phase, 310 beds will be set up along with 12 departments and four units. The beds will include 163 normal beds, 54 ICU beds, 28 HDU beds, 20 isolation beds and 45 private beds.

In the second phase, an additional 265 beds will be included along with nine more departments and two units. This phase will comprise installation of 158 normal beds, 13 ICU beds, 10 HDU beds, 21 isolation beds and 63 private beds, the director said.

He informed that in the first phase, 12 departments and 4 units will function. These include departments like General Pediatrics, Pediatric Oncology, Pediatric Emergency, Pediatric Critical Care, Pediatric Surgery, Pediatric Gastroenterology and Pediatric Endocrinology.

Meanwhile, the units will encompass Pediatric Pulmonology, Pediatric Cardiology, Day Care and Pediatric Medical Genetics. (PTI)

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